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Bystimulating presynaptic 5-HT1A autoreceptors, itreduces the activity of dorsal raphe serotonergicneurones.

Although results have beenconflicting, a large study that controlled for blood con-tamination in CSF observed a lower ?-synuclein concen-tration in patients with PD than in controls or in patientswith AD (Hong et al., 2010).